Malaria

Vectorial capacity

VC = m a^2 p^n

• m= mosquito density
• a= man biting habit
• p= probability of mosquito surviving a full day after being infected
• n= number of days in the extrinsic cycle

Clinical malaria

• Mild: use po meds: quinine, cholraquine, ACT (second drug reduces recrudescence)
• Severe pediatricuse iv quinine (careful of hypoglycemia), artesunate
  • Severe anaemia
  • Hypoglycemia
  • Cerebral malaria: altered mental status/coma
  • Rapid breathing
  • Rare shock
  • Almost never: ARDS, renal
• Severe adults: use iv quinine (careful of hypoglycemia), artemisinin
  • Cerebral malaria
  • ARDS
  • Renal failure
  • Hepatic failure
  • DIC
  • Rarely:
    • Hypoglycemia (usu. kids)
    • Anemia (usu. kids)
• Be careful: pregnancy, high parasitemia, presence of schizonts (P.f.)